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Role of lubricin and boundary lubrication in the

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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Supramolecular synergy in the boundary lubrication of .

Boundary lubrication measured in the SFB arises from dissipation at the slip plane between the intimately contacting boundary layers ... The role of lubricin in the mechanical behavior of ...

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Biotribological Assessment for Artificial Synovial Joints .

Biotribological Assessment for Artificial Synovial Joints: The Role of Boundary Lubrication Doctorate of Philosophy in Biomedical Engineering by LORNE R GALE, BE(Mech, Hons) Thesis submitted for the degree of Doctor of Philosophy, School of Engineering Systems, Institute of Health and Biomedical Innovation (IHBI),

Role of lubricin and boundary lubrication in the .

Lubricin, a mucinous glycoprotein produced by synovial cells and superficial zone chondrocytes (11, 14), provides lubrication in the boundary mode . Boundary lubrication dominates during periods of high load and low velocity, when the lubricant film layer is thinner than the surface roughness .

Lubricin - Brown Universi

provides lubrication but does not prevent wear, enabling a pencil to leave a residue (writing). Lubricin lubricates via the boundary mode which is a regime in the leftward area of the Striebek curve (Márton & Lantos, 2006). This means that boundary lubrication functions independently of synovial fluid viscosity.

Proteoglycan 4 - Wikiped

Function. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

The biology of Lubricin: Near frictionless joint motion .

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

The role of lubricin in the mechanical behavior of .

Request PDF on ResearchGate | The role of lubricin in the mechanical behavior of synovial fluid | Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on ...

Friction force microscopy of lubricin and hyaluronic acid .

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Lubricin: a novel potential biotherapeutic approaches for .

Therefore, a treatment with lubricin which would protect cartilage in vivo would be desirable. This article reviews recent findings with regard to the possible role of lubricin in the progression of OA, and further discusses lubricin as a novel potential biotherapeutic approaches for the treatment of OA.

The role of lubricin in the mechanical behavior of .

Abstract Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Role of lubricin and boundary lubrication in the .

Request PDF on ResearchGate | Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Osteoarthritis is a complex disease involving the mechanical breakdown of ...

Supramolecular synergy in the boundary lubrication of .

Boundary lubrication measured in the SFB arises from dissipation at the slip plane between the intimately contacting boundary layers ... The role of lubricin in the mechanical behavior of ...

The role of lubricin in the ... - PubMed Central (PM

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

The role of lubricin in the ... - PubMed Central (PM

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

Role of lubricin and boundary lubrication in the .

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis: Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C ...

Boundary Lubrication - an overview | ScienceDirect Topi

Boundary lubrication involves a single monolayer of lubricant molecules, which are absorbed onto each of the bearing surfaces. This avoids surface wear by impeding the direct contact of surfaces (Hsu and Gates, 2000). The synovial fluid constituent responsible for the boundary lubrication is a specific glycoprotein, termed ‘lubricin’.

The role of lubricin in normal and pathological joint .

of lubricin, including lubrication and cytoprotection. Lubricin plays an important role in articular joint physiology, and the loss of accumu-lation of lubricin may be a factor in the pathology of osteoarthritis (OA) (Figure 1). Therefore, a recent study8 demonstrated that recombi-nant lubricin has a role in chondro-protection in an animal OA model

Full-Length Recombinant Human Proteoglycan 4 Interacts .

Abstract. Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) cartilage boundary lubricating ability of purified rhPRG4, both ...